Clinical Trials

BREAST MM-121-02-02-10 (SHERBOC)   Metastatic Breast Cancer
SHERBOC: A Double-blind, Placebo-controlled, Phase 2 trial of Seribantumab Plus Fulvestrant in Postmenopausal Women with Hormone Receptor-positive, Heregulin Positive (HRG+), HER2 Negative Metastatic Breast Cancer Whose Disease Progressed After Prior Systemic Therapy
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LUNG:   MK3475-598 –  1st line, Untreated, Stage IV/ Metastatic
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plus Ipilimumab vs Pembrolizumab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors are PD-L1 Positive (TPS ≥ 50%) (KEYNOTE-598)
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LUNG:   DIV-SCLC-301 –  2nd line, Relapsed or Refractory
A Two-Part, Open-Label, Randomized, Phase II/III Study of Dinutuximab and Irinotecan versus Irinotecan for Second Line Treatment of Subjects with Relapsed or Refractory Small Cell Lung Cancer
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LYMPHOMA:   CA209-812 (CHECKmate 812) –  Advanced Stage CHL
Randomized, Open-label, Phase 3 Trial of Nivolumab plus Brentuximab vedotin versus Brentuximab vedotin alone in Participants with Relapsed Refractory or Ineligible for Autologous Stem Cell Transplant (ASCT) Advanced Stage Classical Hodgkin Lymphoma
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LYMPHOMA:   MOR208C204  (MORPHOSYS) – R-RDLBCL
Phase II/III, Randomised, Multicentre Study of MOR00208 with Bendamustine versus Rituximab with Bendamustine in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R-R DLBCL) Who Are Not Eligible for High-Dose Chemotherapy (HDC) and Autologous Stem-Cell Transplantation (ASCT) – B-MIND
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MULTIPLE CANCERS:   EAY131 (MATCH)
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma
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PANCREATIC: EP-GF-301 – 2ND Line, Metastatic
A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared with Flourouracil (5-FU) in Patients with Metastatic Pancreatic Adenocarcinoma Previously Treated with Gemcitabine
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NEUROLOGICAL DISEASES:   992FD001  – Behavioral Variant Frontotemporal Dementia (bvFTD)
A Study to Model Rates of Change on Neuropsychological Test Measures in Subjects Diagnosed With Behavioral Variant Frontotemporal Dementia and Healthy Subjects (FORWARD)
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PULMONARY:   TDE-HF-301 (SOUTHPAW) – Pulmonary Hypertension
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)
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PULMONARY:   TDE-HF-302 (SOUTHPAW) – Pulmonary Hypertension (Long Term Follow-Up)
An Open-label Extension Study of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) Associated with Heart Failure with Preserved Ejection Fraction (HFpEF) – A Long-Term Follow-up to Study TDE-HF-301
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PULMONARY:   TDE-PH-401 (ADAPT) – Pulmonary Atrial  Hypertension
ADAPT – A Patient Registry of the Real-world Use of Orenitram®
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PULMONARY:   RIN-PH-201 (INCREASE) – Pulmonary Hypertension PLD
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Subjects with Pulmonary Hypertension due to Parenchymal Lung Disease
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PULMONARY:   RIN-PH-202 (INCREASE-OL) – Pulmonary Hypertension PLD
An Open-Label Extension study of Inhaled Treprostinil in Subjects with Pulmonary Hypertension due to Parenchymal Lung Disease
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RADIATION THERAPY: NRG BN-001 –  Brain
Randomized Phase II Trial Of Hypofractionated Dose-Escalated Photon IMRT OR Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant And Adjuvant Temozolomide In Patients With Newly Diagnosed Glioblastoma
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RADIATION THERAPY:   PRO 1401– Prostate
A Phase II Study of Hypofractionated Image Guided Proton Therapy for Low and Intermediate Risk Prostate Cancer
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RADIATION THERAPY:   PARTIQoL 11-497    Prostate
PARTIQoL: Prostate Advanced Radiation Technologies Investigating Quality of Life: A Phase III Randomized Clinical Trial of Proton Therapy vs. IMRT for Low or Intermediate Risk Prostate Cancer
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RADIATION THERAPY:   11-497  PARTIQoL  Registry    Prostate
PARTIQoL: Prostate Advanced Radiation Technologies Investigating Quality of Life: A Phase III Randomized Clinical Trial of Proton Therapy vs. IMRT for Low or Intermediate Risk Prostate Cancer
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RADIATION THERAPY:   PRO 0425 – Proton Cancer Registry
Registry Study for Proton Therapy Clinical Outcomes and Long-Term Follow-up
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RADIATION THERAPY: RADCOMP (RTOG 3510/ RTOG 3509) –  Breast
Pragmatic Phase Iii Randomized Trial Of Proton Vs. Photon Therapy For Patients With Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (Radcomp) Consortium Trial
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RADIATION THERAPY: RTOG 1308 –  Non-Small Cell Lung
Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC
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SPECIMEN COLLECTION:   SERATRIALS 05035 – Prospective Collection of Samples for Research
Collection of blood for patients diagnosed or being treated for one or more health conditions or illnesses of any kind.  Samples obtained from this study will be used in the development and improvement of diagnostic test kits and devices, biomarker discovery, as control specimens or as well as general disease state, clinical/medical research. In addition, the samples may be stored and used for future genetic testing and may include studying the relationship between genes and their linkage to various disease indications.

SPECIMEN COLLECTION:   SERATRIALS 15003 – Additional Bone Marrow Collection for Research
Collection of additional 5-10ml bone marrow during already scheduled procedure.  Samples obtained from this study will be used in the development and improvement of diagnostic test kits and devices, biomarker discovery, as control specimens or as well as general disease state, clinical/medical research. In addition, the samples may be stored and used for future genetic testing and may include studying the relationship between genes and their linkage to various disease indications.

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